Demand for vaccination, as well as access to it, is uneven and sluggish across various parts of India. This article delves into the explanations for this variation from a demand perspective. We find a positive correlation between literacy and the first dose of vaccination. A similar trend is discernible for the demand for vaccines. Also, we find that higher literacy is associated with greater vaccine coverage among women. This nexus between literacy and health preparedness is further substantiated by our findings at the micro-level from an adult literacy evaluation study conducted in early 2021. About 80% of the literate women we surveyed were aware of the COVID-19 symptoms, compared to only 19% surveyed illiterate women. We found that literate women are more likely to wear masks properly and follow COVID-19 protocols and keep abreast with the news and information about COVID-19.